Temporal changes in the cerebrospinal fluid level of hypocretin-1 and histamine in narcolepsy. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy. The pathophysiologic basis of secondary narcolepsy and hypersomnia. Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function. This paper shows that NT2 may be caused by partial loss of the orexin neurons. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. International Classification of Sleep Disorders 3rd edn (AASM, 2014). This paper demonstrates that orexin neurons co-express dynorphin and NARP and that narcolepsy is due to a loss of the orexin neurons, not just a reduction in orexin expression.Īmerican Academy of Sleep Medicine. Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. This study also shows a lack of orexin in the brains of people with narcolepsy.Ĭrocker, A. Reduced number of hypocretin neurons in human narcolepsy. This paper highlights the discovery of a lack of orexin in the brains of people with narcolepsy. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Hypocretin (orexin) deficiency in human narcolepsy. Nishino, S., Ripley, B., Overeem, S., Lammers, G. This article is one of the first to describe the orexin neuropeptides. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. This paper is one of the first descriptions of the orexin neuropeptides (naming them hypocretins). The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. Prevalence of narcolepsy in King County, WA, USA. Prevalence of narcolepsy-cataplexy in Korean adolescents. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study.
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